Stimulated Ovulation Cycle

The main steps involved in this cycle are:

  • Super-Ovulation:
    Naturally, in each ovarian cycle one follicle becomes mature and gets ready for fertilization. Now women who have infertility problem and is going to undergo IVF, FSH are given as subcutaneous (under the skin) injection that will regulate ovulation, the growth and development of eggs in the ovaries.[4]
Administration of FSH for Ovarian follicle stimulation
  • Trans-vaginal Ultrasound: 
    After FSH treatment, ultrasound scans are needed to monitor the response of the follicles growth in the ovaries. The growth of the follicles is assessed by observing their increase in size using a trans-vaginal ultrasound.[4]
Trans-vaginal Ultrasound

If the follicles seen on the scan is in the range of 16 mm to 20 mm in size, then the trigger shot is given as mentioned in the next step. This hormone initiates the final maturation and release of the eggs. This mimics the LH surge that stimulates ovulation during normal cycle.

  • Taking a hCG shot:
    The next step in IVF treatment is triggering the oocyte for the last stage of maturation, before retrieval. This last growth is triggered with an injection. This is also called the “hCG (human Chorionic Gonadotrophin) Trigger shot”.[4]
hCG trigger shot

 

The injection is given when the follicles have grown in range of 16 to 20 mm in size. This shot is typically a one-time injection.

 

  • Going for the Gold- Retrieval of Eggs:
    About 34 to 36 hours after the “trigger shot” is received, the egg retrieval or ovum pick up will take place.
Retrieval of the egg

 

 

References:

  1. cimarindia.org/specialities/fertility/ivf-treatment/
  2. www.lifefertility.com.au/ivf-step-by-step/
  3. http://www.fertilitytoday.org/frequent_questions.html
  4. http://www.thebridgeclinic.com/Doctors-on-fertility/entryid/68/steps-to-ivf-treatment-administration-of-drugs

 

Introduction to RoboICSI®

RoboICSI® is an award-winning device to assist the embryologist during IVF towards improving the outcomes, thus helping infertile couples bear a child. Based on a novel design technique, RoboICSI® is a patent-pending device that will help bridge the gap between the demand and supply in the explosively growing infertility industry. It will be a Made-in-India device that will be a pioneer, offering several features for the First time in the World.

It is a smart device, which helps the embryologist to perform ICSI in an enhanced manner. RoboICSI® substitutes the holding pipette that is being used in the conventional ICSI.

Here is a quick overview about RoboICSI

 

Benefits of RoboICSI®

  • Novel micro-manipulation

RoboICSI® offers a novel way to grasp cells using bio compatible material, which offer several advantages compared to the traditional micro-pipette aspiration-based immobilization

  • Gentle handling of cells

RoboICSI® ’s intelligent passive force-limiting technology ensures that the oocyte that is grasped is not damaged even if the embryologist makes a mistake

  • Quick and hassle-free installation

RoboICSI® is designed and developed keeping in mind the current devices that are used in ICSI workbenches. RoboICSI®’s plug-and-play system allows the user to quickly plug the system, perform and the auto-calibration and get started in about a day

  • Easy onboarding and seamless integration

RoboICSI® is easy to learn, which allows clinics to add it into their workflow without much hassle

  • Eliminates subjectivity while handling oocytes

Performs routine tasks and reduces fatigue.Augments the embryologists and maximizes their potentials

  • Enables the IVF clinics to handle more volumes

Advantages of RoboICSI® over conventional ICSI

  • Easy-to-handle

RoboICSI® is a robust device. It replaces the use of pneumatic pump, making it easier to handle with an easy-to-use and intuitive control.

  • Not-fragile

The conventional ICSI holding pipette is made of glass and has a tendency to break while handling the oocytes. RoboICSI® replaces the glass pipette with a Holder made up of silicone elastomer, which is not fragile.

  • Automated

Data is collected automatically throughout the process.

  • Gentle manipulation of oocytes

The Holder which is designed to be soft, ensures no oocytes are harmed during the ICSI procedure (even inadvertently).

What is ICSI

Intracytoplasmic sperm injection (ICSI) is an ART involving the injection of a single sperm into the cytoplasm of an oocyte to achieve fertilization. It is mainly performed for the treatment of couples with male factor infertility and those with poor fertilization with conventional IVF.

ICSI is the only treatment option for couples with severe male factor infertility. It can be performed with ejaculated or surgically retrieved sperm.

Intracytoplasmic Sperm Injection

Infertility Treatments

Assisted Reproductive Technology (ART), according to WHO, refers to infertility treatments where both eggs (oocytes) and sperm are handled ex-vivo to achieve pregnancy. In conventional ART procedures, the oocytes and sperms are combined in a laboratory ex vivo (i.e. outside the human body) and the resulting embryo (mature and fertilized oocyte) is implanted back into a woman.

ART’s includes techniques such as In-vitro fertilization (IVF), Intracytoplasmic Sperm Injection (ICSI), Gamete Intra-Fallopian Transfer (GIFT) or Zygote Intra-Fallopian Transfer (ZIFT) .